Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer

Table 2 Oncogenes and tumor suppressor genes, whose products participate in regulation of cancer cells metabolism

Oncogene/tumor suppressor	Metabolic pathway	Enzyme	Ref.
MYC	Glucose transport	GLUT1	[53-55]
	Glycolysis	Hexokinase 2
		Phosphohexose isomerase
		Phosphofructokinase 1
		Aldolase A
		3-phosphoglyceraldehyde dehydrogenase
		Phosphoglycerate kinase
		Phosphoglycerate mutase
		Enolase 1
		Pyruvate kinase 2
		Lactate dehydrogenase A
	Regulation of PDH	Pyruvate dehydrogenase kinase 1
	Glutamine transport	Glutamine transporters ASCT2 and SN2
	Glutaminolysis	Glutaminase 1
	Serine hydroxymethyltransferase
	Pyrimidine synthesis
	Aminoacids metabolism	CAD
		Ornithine decarboxylase
	Lipogenesis	Fatty acid synthase
p53	Glucose transport	GLUT1	[51,56-60]
	Glycolysis	Hexokinase 2
		Fructose-2,6-bisphosphatase
		Phosphoglycerate mutase
	Oxidative phosphorylation	Cyrochrome c oxidase
	Glutaminolysis	Glutaminase 2
	Pentose Phosphate Pathway	Glucose-6-phosphate dehydrogenase
	Regulation of PDH	Pyruvate dehydrogenase kinase 1
	Krebs cycle	Aconitase
KRAS	Glucose transport	GLUT1	[61,73,94]
	Glycolysis	Hexokinase 2
		Phosphofructokinase 1
		Lactate dehydrogenase A
	Pentose phosphate pathway	Transketolase
	Hexosamine synthesis	Phosphohexose aminotransferase
	Glutaminolysis	Glutamate dehydrogenase
		Aspartate transaminase
Akt/PTEN	Glucose transport	GLUT1	[50,113-115]
	Lipogenesis	FASN