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Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 28, 2014; 20(8): 1972-1985
Published online Feb 28, 2014. doi: 10.3748/wjg.v20.i8.1972
Table 4 Effects of perioperative administration of erythropoietin and iron on transfusion requirements in patients undergoing elective colorectal cancer resection
Study+ESA
Placebo
IronESA
nABT, n (%)nABT, n (%)(route, type, dose, d)(type, total dose, route, day)
Braga et al[75]101 (10)1105 (50)iv iron gluconate, 125 mg/d, 4 dEpoetin alfa,
500 IU/kg, SC
(from day -12 to day +8)
Kettelhack et al[76]4816 (33)5415 (28)Oral, NS, 5-10 d preOPEpoetin beta,
iv, NS, 40 mg, 1 d postOP3000-4500 IU/kg, SC
(from day -10 to day +4)
Qvist et al[77]3813 (34)24323 (53)Oral, NS,Epoetin alfa,
200 mg/d, 4 d1350 IU/kg, SC
(from day -4 to day +7)
Kosmadakis et al[78]319 (29)13219 (59)iv iron sucrose,Epoetin alfa,
100 mg/d, 14 d4200 IU/kg, SC
(from day -7 to day +7)
Christodoulakis et al[79]69 (a)34 (49)6835 (51)Oral, NS,Epoetin alfa,
67 (b)27 (40)2200 mg/d, 10 d1800 IU/kg, SC (a)
3600 IU/kg, SC (b)
(from day -10 to day +1)
Norager et al[80]7510 (13)769 (12)Oral, NS,Darbepoetin alfa,
200 mg/d, 7d750-1500 g, SC
(from day -10 to day +25)
Overall338110 (33)283106 (37)OR = 0.89 (95%CI: 0.58-1.12; P = 0.206)