New genes emerging for colorectal cancer predisposition

doi:10.3748/wjg.v20.i8.1961

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Feb 28, 2014; 20(8): 1961-1971
Published online Feb 28, 2014. doi: 10.3748/wjg.v20.i8.1961

Table 3 Genetic variants associated with colorectal cancer susceptibility identified by genome-wide association studies (as for September 2013)

SNP	Region	Gene	Sample size (cases/controls)	Effect size OR (95%CI)
rs693267	8q24.21	MYC	8264/6206	1.21 (1.15-1.27)
rs4939827	18q21.1	SMAD7	8413/6949	1.18 (1.12-1.23)
rs16892766	8q23.3	EIF3H	18831/18540	1.25 (1.19-1.32)
rs3802842	11q23.1	?	14500/13294	1.12 (1.07-1.17)
rs4779584	15q13.3	GREM1	7922/6741	1.26 (1.19-1.34)
rs10795668	10p14	?	18831/18540	1.12 (1.10-1.16)
rs4444235	14q22.2	BMP4	20288/20971	1.11 (1.08-1.15)
rs9929218	16q22.1	CDH1	20288/20971	1.10 (1.06-1.12)
rs10411210	19q13	RHNP2	20288/20971	1.15 (1.10-1.20)
rs961253	20p12.3	BMP2	20288/20971	1.12 (1.08-1.16)
rs6691170	1q41	DUSP10	18185/20197	1.06 (1.03-1.09)
rs10936599	3q26.2	TERC	18185/20197	0.93 (0.91-0.96)
rs11169552	12q13.3	?	18185/20197	0.92 (0.90-0.95)
rs4925386	20q13.33	LAMA5	18,185/20,197	0.93 (0.91-0.95)
rs1957636	14q22.2	BMP4	24910/26275	1.08 (1.05-1.11)
rs4813802	20p12.3	BMP2	24910/26275	1.09 (1.06-1.12)
rs2736100	5p15.33	TERT	16039/16430	1.07 (1.04-1.10)
rs1321311	6p21	CDKN1A	21096/19555	1.10 (1.07-1.13)
rs3824999	11q13.4	POLD3	21096/19555	1.10 (1.07-1.13)
rs5934683	Xp22.2	SHROOM2	21096/19555	1.07 (1.04-1.10)
rs12080929	1p33	SLC5A9	2317/2447	0.86 (0.78-0.95)
rs11987193	8p12	DUSP4	2317/2447	0.78 (0.70-0.87)
rs10774214	12p13.32	CCND2	11870/14190	1.04 (1.00-1.09)
rs647161	5q31.1	PITX1	11870/14190	1.07 (1.02-1.11)
rs2423279	20p12.3	HAQ1	11870/14190	1.07 (1.03-1.12)
rs11903757	2q32.3	NABP1	15752/21771	1.16 (1.10-1.22)
rs10911251	1q25.3	LAMC1	15752/21771	1.09 (1.06-1.13)
rs3217810	12p13.32	CCND2	13654/16022	1.20 (1.12-1.28)
rs3217901	12p13.32	CCND2	15752/21771	1.10 (1.06-1.14)
rs59336	12q24.21	TBX3	15752/21771	1.09 (1.06-1.13)

Citation: Esteban-Jurado C, Garre P, Vila M, Lozano JJ, Pristoupilova A, Beltrán S, Abulí A, Muñoz J, Balaguer F, Ocaña T, Castells A, Piqué JM, Carracedo A, Ruiz-Ponte C, Bessa X, Andreu M, Bujanda L, Caldés T, Castellví-Bel S. New genes emerging for colorectal cancer predisposition. World J Gastroenterol 2014; 20(8): 1961-1971
URL: https://www.wjgnet.com/1007-9327/full/v20/i8/1961.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i8.1961