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Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 28, 2014; 20(8): 1961-1971
Published online Feb 28, 2014. doi: 10.3748/wjg.v20.i8.1961
Table 1 Hereditary colorectal cancer genes
GeneChromosomeMendelian patternFunction
Familial adenomatous polyposisAPC5qADRegulation of canonical Wnt signaling pathway
MUTYH1pARBase-excision repair
Hereditary non-polyposis CRC (Lynch syndrome)MLH13pADMismatch repair
MSH22pADMismatch repair
MSH62pADMismatch repair
PMS27pADMismatch repair
Peutz-JeghersLKB119pADRegulation of Wnt signaling pathway
Juvenile polyposisSMAD418qADTGFBR signaling pathway
BMPR1A10qADTGFBR signaling pathway
Cowden’s diseasePTEN10qADNegative regulation of PI3K signaling
KLLN10qADApoptotic process