Possible roles of insulin, IGF-1 and IGFBPs in initiation and progression of colorectal cancer

Table 4 Comparisons of serum biomarker levels between colon cancer and rectal cancer patients (x bar ± s)

Biomarker	Colon cancer (n = 65)	Rectal cancer (n = 167)	P value
Insulin (μIU/mL)	8.04 ± 3.86	10.01 ± 4.86	0.095
Leptin (ng/mL)	12.80 ± 5.81	13.76 ± 5.69	0.144
IGF-1 (ng/mL)	181.01 ± 38.01	207.39 ± 39.62	0.041
IGFBP-1 (ng/mL)	9.82 ± 1.81	11.99 ± 4.28	0.022
IGFBP-3 (μg/mL)	6.04 ± 2.19	6.31 ± 3.66	0.73
IGF-1/IGFBP-3	30.81 ± 9.64	39.57 ± 15.24	0.033

IGF-1: Insulin-like growth factor-1; IGFBP: Insulin-like growth factor binding protein.