An association between Helicobacter pylori and upper respiratory tract disease: Fact or fiction?

Table 7 Detection of Helicobacter pylori in investigations of relationships between Helicobacter pylori and head and neck malignancies

Ref.	Patients(n)	Samples	Methods	Positive results
Siupsinskiene et al[227]	13	Laryngeal tissue	Urease test	46.2%
Shi et al[230]	59	Laryngeal tissue	PCR	76.3%
Aygenc et al[231]	26	Blood	ELISA	73.1%
Okuda et al[232]	58	Oral swab	PCR	100%
Burduk[233]	80	Laryngeal tissue	Urease test	62.5%
Dayama et al[234]	20	Oral tissue	Culture	15%
			PCR	15%
Rubin et al[235]	53	Blood	ELISA	64.2%
Rezaii et al[236]	98	Blood	ELISA	93.9%
Gong et al[237]	81	Laryngeal tissue	PCR	71.6%
		Blood	ELISA	77.8%
Grimm [238]	191	Oral tissue	IHC	21.5%
Kizilay et al[241]	69	Laryngeal tissue	Histology	0%
Akbayir et al[242]	50	Laryngeal tissue	IHC	0%
Pirzadeh et al[243]	65	Laryngeal tissue	Urease test	0%
			Histology	0%
Kanda et al[244]	31	Laryngeal tissue	PCR	0%
			Culture	0%
			IHC	0%
		Urine	ELISA	67.7%
Grandis et al[245]	21	Blood	ELISA	57%
Nurgalieva et al[246]	119	Blood	ELISA	32.8%
Lukeš et al[248]	11	Oropharyngeal lymphoid tissue	Culture	9.1%
	23	Oropharyngeal lymphoid tissue	PCR	73.9%
	41	Blood	ELISA	78.1%
Pavlík et al[249]	3	Blood	ELISA	0%
		Tonsillar tissue	PCR	100%

ELISA: Enzyme-linked immunosorbent assay; PCR: Polymerase chain reaction.