An association between Helicobacter pylori and upper respiratory tract disease: Fact or fiction?

Table 6 Detection of Helicobacter pylori in investigations of relationships between Helicobacter pylori and benign pharyngeal/laryngeal diseases

Ref.	Patients(n)	Samples	Methods	Positive results
Pharyngeal disease
Aladag et al[208]	41	Blood	ELISA	78%
Zhang et al[211]	50	Pharyngeal tissue	Histology	38%
Kaptan et al[212]	70	Pharyngeal tissue	PCR	27.1%
			Culture	5.8%
Elsheikh et al[213]	146	Pharyngeal tissue	PCR	32.9%
Laryngeal disease
Ozyurt [52]	27	Laryngeal tissue	PCR	58.6%
Burduk et al[58]	30	Laryngeal tissue	PCR	100%
Cekin et al[215]	43	Laryngeal tissue	PCR	55.8%
Youssef et al[217]	212	Stool	ELISA	57.5%
Rubin et al[222]	101	Blood	ELISA	54.5%
Talaat et al[223]	162	Stool	ELISA	86.4%
Tiba M et al[224]	14	Laryngeal tissue	PCR	71.4%
			IHC	71.4%
Borkowski et al[226]	35	Laryngeal tissue	Urease test	17.1%
Siupsinskiene et al[227]	54	Laryngeal tissue	Urease test	37.0%
Jaspersen et al[228]	38	Gastric tissue	Urease test	36.8%
		Laryngeal swab	Culture	0%

ELISA: Enzyme-linked immunosorbent assay; IHC: Immunohistochemistry; PCR: Polymerase chain reaction.