Tricistronic hepatitis C virus subgenomic replicon expressing double transgenes

Figure 4 Response of sH7 cells to antivirals. sH7 cells stably transfected with tricistronic hepatitis C virus (HCV) replicon were treated with ribavirin (A and B), HMG CoA reductase inhibitors (simvastatin and atorvastatin; C and D), and NS3/4A serine protease inhibitors (telaprevir and boceprevir; E and F). All three types of antivirals suppressed replication of tricistronic HCV replicons in sH7 cells in a dose- and time-dependent manner. The relative light units were normalized to those in untreated sH7 wells as a control.