Non invasive tools for the diagnosis of liver cirrhosis

Table 2 Principal scoring systems taking into account the parameters used in calculating the scores, etiology of liver disease and sensitivity and specificity values of the tests

Test	Parameters	Etiology	Sensitivity	Specificity
Age-platelet index (AP)[55]	Age, platelet count	HCV	52%	93%
APRI[56]	AST/platelet count	HCV	57%	93%
ASPRI[57]	Age, spleen diameter, platelet count	HBV	75%	90%
AST/ALT ratio[58]	Aspartate aminotransferase, alanine aminotransferase	HBV	51%	71%
BARD score[59]	BMI, AST/ALT ratio, diabetes	NAFLD	62%	66%
Bonacini-index (Cirrhosis discriminant score - CDS)[60]	ALT/AST ratio, INR, platelet count	HCV	46%	98%
ELF and simplified ELF index[61]	Age, Hyaluronic acid, N-terminal propeptide of type II collagen, and TIMP-1 levels	Mixed	90%	69%
FIB-4[62]	Platelet count, AST, ALT, age	HIV/HCV	65%	97%
Fibro-α score[63]	Platelet count, AST, ALT, α-fetoprotein level	HCV	90%	57%
Fibroindex[64]	Platelet count, AST, γ-globulin	HCV	35%	97%
Fibrometer test[65]	Platelet count, prothrombin index, AST, α2-macro-globulin, hyaluronan,urea, age	VirusAlcohol	80%91%	84%92%
Fibrometer NAFLD[66]	Glucose, AST, ALT, ferritin, platelet count, body weight, age	NAFLD	79%	96%
Fibronectin discriminant score[67]	Platelet count, AST, Albumin and fibronectin levels	HCV	87%	75%
FibroQ[68]	Age, platelet count, AST, ALT, Prothrombin index	HBV/HCV	79%	71%
Fibrosis-cirrhosis index[69]	Platelet count, Alkaline phosphatase, bilirubin, albumin levels	HCV	86%	80%
Fibrosis index[70]	Platelet count, Albumin level	HCV	67%	97%
Fibrosis probability index(Sud index)[71]	Age, AST, Total cholesterol level, insulin resistance and alcohol intake	HCV	73%	74%
Fibrosis Routine Test[72]	Age, platelet count, AST, α-fetoprotein and albumin levels	HCV	83%	73%
FibroSpect II[73]	hyaluronan, TIMP-1,α2-macroglobulin	HCV	76%	73%
Fibrotest[74]	Haptoglobin, α2-macroglobulin, apolipoprotein A1, γGT, bilirubin, gender	HCV	75%	85%
Forns-index[75]	Age, platelet count, γGT, cholesterol	HCV	30%	95%
Globulin-albumin ratio[76]	Globulin and albumin levels	HCV	43%	98%
GUCI[77]	Platelet count, AST, Prothrombin index	HCV	80%	78%
HALT-C model[78]	Platelet count, TIMP-1 and hyaluronic acid levels	HCV	71%	80%
Hepascore[79]	Bilirubin, γGT, hyaluronan, α2-macroglobulin, age, gender	HCV	84%	71%
King’s score[80]	Age, platelet count, AST, INR	HCV	86%	80%
Lok index[81]	Platelet count, AST, ALT, INR	HCV	68%	72%
MP3 score[82]	MMP-1 and PIIIP levels	HCV	60%	92%
NAFLD fibrosis score[83]	Age, hyperglycemia, BMI, platelet count, albumin, AST/ALT ratio (dual cut-offs)	NAFLD	77%	96%
Pohl index[84]	Platelet count, AST, ALT	HCV	41%	99%
Sabadell NIHCED index[85]	Age, platelet count, AST, ALT, Prothrombin time, right hepatic lobe atrophy, splenomegaly, and caudate lobe hypertrophy	HCV	80%	96%
Significant fibrosis index[86]	Haptoglobin, α2-macroglobulin, TIMP-1, MMP-2, and GGT levels	HBV/HCV	71%	80%
VITRO score[87]	vWF-Ag, platelet count	HCV	83%	79%
Zeng index[88]	Age, α2-Macroglobulin, GGT, and hyaluronic acid levels	HBV	40%	90%

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; BMI: Body mass index; ELF: Enhanced liver fibrosis; NAFLD: Non-alcoholic fatty liver disease; TIMP: Tissue inhibitors of metalloproteinases; MMP-1: Matrix metalloproteinase-1; GGT: γ-glutamyl transferase.