MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease

Figure 6 Role of microRNA-185 in the regulation of insulin signalling transduction and lipid metabolism. MicroRNA-185 up-regulates the key effector insulin receptor substrate-2 (IRS-2), which in turn activates the phosphatidylinositide 3-kinase/Akt2 signalling that increases insulin sensitivity. On the other hand, miR-185 represses SREBP-1c and 2, which ultimately results in decreased lipid synthesis. SREBP-1C: Sterol-regulatory element-binding proteins 1C; SREBP-2: Sterol-regulatory element-binding proteins 2; FAS: Fatty acid synthase.