Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells

Table 2 Top molecular and cellular functions, upstream regulators, and networks of claudin1 according to ingenuity pathway analysis

Name	P value	Molecules	Score
Top molecular and cellular functions
Cellular movement	2.77 × 10-9-1.01 × 10-2	51
Cell-to-cell signaling and interaction	7.24 × 10-7-1.02 × 10-2	55
Molecular transport	1.23 × 10-6-9.98 × 10-3	51
Small molecule biochemistry	1.23 × 10-6-9.98 × 10-3	55
Cellular development	3.80 × 10-6-9.50 × 10-3	59
Top upstream regulators
TNF-RSF1A	1.80 × 10-7
TNF-	1.70 × 10-6
NF-κB (complex)	2.01 × 10-6
Escherichia coli B5 lipopolysaccharide	2.09 × 10-6
NF-κB1	3.23 × 10-6
Top networks
Associated network functions
Cellular assembly and organization, hair and skin development and function, cellular function and maintenance			33
Cell-to-cell signaling and interaction, cellular growth and proliferation, tissue morphology			32
Cellular movement, hematological system development and function, immune cell trafficking			31
Cardiovascular system development and function, organismal development, cellular movement			22
Hereditary disorder, respiratory disease, tissue development			22

TNF-: Tumor necrosis factor; NF: Nuclear factor.