Meta-analysis of laparoscopic vs open cholecystectomy in elderly patients

Table 1 Study characteristics

Ref.	Year	Study design	Period	Patients (n) (lap/open)	Age	Investigated outcomes	ITT/AT	NOS
Massie et al[15]	1993	Retrospective	1990-1991	58	> 70	Morbidity	NR	3
				(33/25)
Feldman et al[4]	1994	Prospective database1	1988-1992	2269	> 65	Mortality	NR	4
				(1508/761)
Lucier et al[5]	1995	Prospective database2	1991-1992	3907	> 65 (mean 73.9 lap, 75.4 open)	Morbidity, mortality, cardiac, respiratory	NR	3
				(1769/2138)
Samkoff et al[6]	1995	Prospective database3	1992-1993	63920	> 65	Morbidity, mortality, respiratory	NR	3
				(29731/34189)
Huang et al[16]	1996	RCT	1992-1993	27	> 70	Morbidity, mortality, cardiac, respiratory	NA	NA
				(15/12)
Lujan et al[17]	1998	RCT	1991-1996	264	> 65 [median 71 (65-87) lap, 72 (65-88) open]	Morbidity, mortality, respiratory	NR	NA
				(133/131)
Maxwell et al[18]	1998	Prospective database4	1988-1992	18500	> 80 (mean, 83.9 lap, 84.0 open)	Mortality	NR	4
				(5034/13466)
Pessaux et al[19]	2001	Prospective	1992-1999	139	> 75 [mean 81.9 (75-98) lap, 81.9 (75-93) open]	Morbidity, mortality, cardiac, respiratory	NR	7
				(50/89)
Fisichella et al[20]	2002	Retrospective	1995-1998	35	> 70 (mean 74 ± 2.4 lap, 74 ± 4.1 open)	Morbidity, mortality, cardiac, respiratory	ITT	4
				(24/11)
Chau et al[21]	2002	Retrospective	1994-1999	73	> 75 (mean 79.2 ± 4.2 lap, 80.7 ± 4.6 open)	Morbidity, mortality, cardiac, respiratory	ITT	5
				(31/42)
Moyson et al[22]	2008	Retrospective	1991-2007	100	> 75 [median 83 (75-94)]	Mortality, morbidity	AT	5
				(85/15)
Leardi et al[23]	2009	Retrospective	2000-2006	341	> 70	Morbidity	NR	4
				(258/83)
Tucker et al[7]	2011	Prospective database5	2005-2008	11926	> 65 [median 73.0 (69-79)]	Mortality, morbidity, cardiac, respiratory	AT	4
				(9524/2402)

¹Connecticut Health Information and Management Exchange;

²Medicare database Indiana;

³8-State Medicare Database;

⁴Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project-3;

⁵American College of Surgeons Quality Insurance Program ACS NSQIP. ITT: Intention-to-treat; NOS: None otherwise specified; NA: Not available; NR: Not reported; AT: As treated analysis.