Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice

Figure 1 Clostridium difficile-induced colitis mouse model. A: Wild type (WT) and interleukin 10-deficient (IL-10^-/-) mice were pre-treated with an antibiotic cocktail for three days followed by an i.p. injection of clindamycin two days later, before being challenged with an oral administration of Clostridium difficile (C. difficile) (cfu, colony forming units); B: The mice were divided into four groups (n = 10 each): a control and C. difficile challenge group each for WT and IL-10^-/- mice. The control groups underwent all pretreatment processes in parallel with the C. difficile challenge groups, but were not administered C. difficile.