Correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis

Figure 1 Schema of the dual supply model and the basic equation for hepatic blood flow of xenon computed tomography. Based on the changes over time in CT values for the hepatic tissues and the spleen, hepatic tissue blood flow (TBF) was calculated by applying the Fick principle using Kety-Schmidt’s equation to obtain arterial blood flow (fa), portal blood flow (fp), and lambda (λ) values in the human liver on a pixel-by-pixel basis in xenon computed tomography (Xe-CT). This dual blood supply model for the liver was used to calculate hepatic blood flow by Xe-CT. Ch(t), Ca(t), Cv(t), and Cpv(t) represent time-dependent Xe concentrations in the liver tissue, arterial blood, venous blood, and portal blood, respectively. Arterial and portal blood flows per unit volume of liver tissue are indicated by fa and fp, respectively. Cp(t) represents the time-dependent Xe concentration in the portal organ tissue, and fpa indicates blood flow per unit volume of portal organ tissue.