MicroRNAs in colorectal cancer: Role in metastasis and clinical perspectives

doi:10.3748/wjg.v20.i45.17011

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 7, 2014; 20(45): 17011-17019
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.17011

Table 1 MicroRNAs involved in angiogenesis

MicroRNAs	Target genes/activators	Effect on angeogenesis	Ref.
miR-194	THBS1	↑ Enhance	[69]
miR-221, miR-222	c-Kit, Stat5A, ENOS, and ETS1	↓ Inhibit	[70]
miR-17-92 (Oncomir-1)	TSP-1 and CTGF	↑ Enhance	[71]
miR-126	SPRED1 and PIK3R2 p85beta	↑ Enhance	[72]
miR-210	Hypoxia-induced miR-210 activation accompanied by KRAS mutation	↑ Enhance	[73]
miR-497	IGF1-R	↓ Inhibit	[74]
miR-424	Hypoxia-induced activation of angiogenic genes	↑ Enhance	[75]

ENOS: Endothelial nitric oxide synthase; ETS1: V-ets erythroblastosis virus E26 oncogene homolog 1; Stat5A: Signal transducer and activator of transcription 5A; CTGF: Connective tissue growth factor; TSP-1: Encodes thrombospondin-1; SPRED1: Sprouty-related protein1; PIK3R2: Phosphatidylinositol-3-kinase regulatory subunit; KRAS: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; IGF1-R: Nsulin-like growth factor 1 receptor gene.

Citation: Muhammad S, Kaur K, Huang R, Zhang Q, Kaur P, Yazdani HO, Bilal MU, Zheng J, Zheng L, Wang XS. MicroRNAs in colorectal cancer: Role in metastasis and clinical perspectives. World J Gastroenterol 2014; 20(45): 17011-17019
URL: https://www.wjgnet.com/1007-9327/full/v20/i45/17011.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i45.17011