Transjugular intrahepatic portosystemic shunts and portal hypertension-related complications

Table 3 Results of 6 randomized controlled trials comparing transjugular intrahepatic portosystemic shunts and large volume paracentesis for refractory ascites

Ref.	Number of patients		Complete resolution of ascites within 6 mo1			Treatment failure2			Survival at 2 yr			Newly developed or severe encephalopathy
	TIPS	LVP	TIPS	LVP	P-value	TIPS	LVP	P-value	TIPS	LVP	P-value	TIPS	LVP	P-value
Lebrec et al[98] 1996	13	12	38%	0%	< 0.05	NR			29%	60%	0.03	45%	0%	< 0.05
Rössle et al[100], 2000	29	31	52%	16%	0.001	10%	48%	0.001	58%	32%	0.11	23%	13%	NS
Ginès et al[97], 2002	35	35	NR			49%	83%	0.003	26%	30%	0.51	60%	34%	0.03
Sanyal et al[102], 2003	52	57	NR			42%	84%	< 0.001	35%	33%	0.84	38%	21%	0.058
Salerno et al[101], 2004	33	33	60%3	3%	< 0.001	21%	57%	0.001	59%	29%	0.021	61%	39%	NS
Narahara et al[99], 2011	30	30	30%	0%	< 0.005	13%	80%	< 0.001	64%	35%	< 0.005	67%	17%	< 0.001

¹By intention-to-treat analysis;

²Needed frequent paracentesis or other treatment modalities to control ascites;

³Evaluated at 1 year after randomization. NR: Not reported; NS: Not significant. LVP: Large volume paracentesis; TIPS: Transjugular intrahepatic portosystemic shunts.