Balloon dilation itself may not be a major determinant of post-endoscopic retrograde cholangiopancreatography pancreatitis

Table 2 Frequency and severity of pancreatitis and complications after endoscopic papillary large balloon dilation with endoscopic sphincterotomy

Ref.	Study design	Study’s location	Comparison groups (n)	Balloon diameter (mm)	Pancreatitisn (%)	Pancreatitis severity (n)			Other complications (n)			Overall AEs-related death (n)
						Mild/moderate	Severe	death	Bleeding	Perforation	Cholangitis
Ersoz et al[31], (2003)	R	Turkey	EPLBD (n = 58)	12-20	2 (3.4)	2	0	0	5	0	2	0
Maydeo et al[60], (2007)	P	India	EPLBD (n = 60)	12-20	0 (0)	0	0	0	5	0	0	0
Minami et al[62], (2007)	R	Japan	EPLBD (n = 88)	20	1 (1.1)	1	0	0	1	0	1	0
Heo et al[61], (2007)	RCT	South Korea	EPLBD (n = 100)	12-20	4 (4.0)	4	0	0	0	0	0	0
			EST (n = 100)	-	4 (4.0)	4	0	0	2	0	0	0
Lee et al[98], (2007)	R	South Korea	EPLBD (n = 55)	15-20	0 (0)	0	0	0	2	0	0	0
Kim et al[99], (2007)	R	South Korea	EPLBD (n = 35)	12-20	0 (0)	0	0	0	0	1	0	0
Lee et al[100], (2007)	R	South Korea	EPLBD (n = 41)	13-20	2 (4.8)	0	0	0	1	0	0	0
Misra et al[101], (2008)	R	India	EPLBD (n = 50)	15-20	4 (8.0)	4	0	0	3	0	0	0
Attasaranya et al[63], (2008)	R	United States	EPLBD (n = 103)	12-18	0 (0)	0	0	0	2	1	0	0
Espinel et al[102], (2008)	P	Spain	EPLBD (n = 93)	12-20	1 (1.1)	1	0	0	1	0	0	0
Itoi et al[103], (2009)	R	Japan	EPLBD (n = 53)	15-20	1 (1.9)	1	0	0	0	0	1	0
			EST (n = 48)	-	2 (4.1)	2	0	0	0	0	1	0
Kim et al[104], (2009)	RCT	South Korea	EPLBD (n = 27)	15-18	0 (0)	0	0	0	4	0	0	0
			EST (n = 28)	-	0 (0)	0	0	0	2	0	0	0
Itoi et al[105], (2010)	R	Japan	EPLBD (n = 18)	15-18	0 (0)	0	0	0	0	0	0	0
Kurita et al[106], (2010)	R	Japan	EPLBD (n = 24)	15-20	0 (0)	0	0	0	0	0	0	0
Ghazanfar et al[107], (2010)	P	Pakistan	EPLBD (n = 84)	15-18	3 (3.6)	3	0	0	3	0	0	1
Kim et al[108], (2010)	R	South Korea	EPLBD (n = 70)	12-18	1 (2.3)	1	0	0	0	0	0	0
Youn et al[65], (2011)	R	South Korea	EPLBD (n = 101)	15-20	2 (2.0)	2	0	0	2	1	0	0
Kim et al[109], (2011)	R	South Korea	EPLBD (n = 72)	12-20	5 (6.9)	5	0	0	0	0	1	0
			EST (n = 77)	-	9 (11.7)	9	0	0	0	1	0	0
Stefanidis et al[75], (2011)	RCT	Greece	EPLBD (n = 45)	15-20	1 (2.2)	1	0	0	1	0	0	0
			EST (n = 45)	-	1 (2.2)	1	0	0	1	1	6	0
Rebelo et al[67], (2012)	R	Portugal	EPLBD (n = 30)	12-18	1 (3.3)	1	0	0	0	0	0	0
Sakai et al[110], (2013)	R	Japan	EPLBD (n = 59)	12-20	0 (0)	0	0	0	1	1	0	0
Park et al[37], (2013)	R	South Korea, Japan	EPLBD (n = 946)	12-20	24 (25.3)	24	0	0	56	9	6	4
Poincloux et al[64], (2013)	R	France	EPLBD (n = 64)	15-20	2 (3.1)	2	0	0	5	0	0	0
Hwang et al[73], (2013)	R	South Korea	EPLBD (n = 69)	12-20	3 (4.3)	3	0	0	0	1	0	0
Paspatis et al[68], (2013)	RCT	Greece	60 s dilation1 (n = 60)	15-20	2 (1.6)	2	0	0	4	1	3	0
			30 s dilation1 (n = 64)	15-20	2 (1.6)	1	1	1	2	1	2	1
Rosa et al[66], (2013)	R	Portugal	EPLBD (n = 68)	12-18	9 (13.2)	9	0	0	0	0	1	0
			EST (n = 45)	-	2 (4.7)	2	0	0	0	0	1	0
Yang et al[111], (2013)	R	China	EPLBD (n = 171)	12-18	2 (1.2)	2	0	0	4	1	1	0
Yoon et al[112], (2013)	P	South Korea	EPLBD (n = 52)	12-20	0 (0)	0	0	0	0	0	0	0
Harada et al[113], (2013)	R	Japan	EPLBD (n = 30)	15-20	0 (0)	0	0	0	0	0	0	0

¹Sixty and thirty seconds mean the duration of balloon dilation (s) in endoscopic papillary large balloon dilation (EPLBD). AEs: Adverse events; EST: Endoscopic sphincterotomy; R: Retrospective; P: Prospective; RCT: Randomized controlled trial.