Potent antiviral therapy improves survival in acute on chronic liver failure due to hepatitis B virus reactivation

Table 4 Studies that have provided long-term data on lamivudine treatment for severe acute exacerbation of chronic hepatitis B

Characteristics	Chan et al[40] 2002, J Viral Heapt	Wong et al[25] 2009, J Gastroenterol Hepatol	Tsubota et al[45] 2005, J Gastroenterol Hepatol	Kumar et al[38] 2006, Dig Dis Sci
Location	Hong Kong	Hong Kong	Japan	India
Follow up	2.5	2.8	2.9	1.5
(median, yr)
ALT (median, IU/L)	1758	1325	816	1658
Bilirubin (median, mg/dL)	31.6	19.6	14.4	10.1
PT/INR (median)	1.63	1.60	1.58	2.0
HBeAg +ve (%)	0	100	70	83
HBV DNA (median, log copies/mL)	6.76	8.08	8.69	5.135
SVR	21/26	21/29	18/21	21/31

SVR defined by Chan and Wong as < 10000 copies/mL; Tsubota as undetectable by bDNa assay (Chiron) and by Kumar as < 600 copies/mL. SVR: Sustained virological response.