Esophageal Helicobacter pylori colonization aggravates esophageal injury caused by reflux

Figure 2 Macroscopic and microscopic findings in the rat esophagus. A: Macroscopic findings in the esophagus: 1, Normal esophagus; 2, Esophagitis with tree bark appearance; 3, Barrett’s esophagus; and 4, esophageal adenocarcinoma. Microscopic findings; B: Normal squamous epithelium (400 × magnification); C: Reflux esophagitis (200 × magnification); D: Barrett’s esophagus (200 × magnification); E: Intestinal metaplasia in the esophagus detected by High-iron diamine-Alcian Blue-Periodic acid-Schiff (400 × magnification); F: Esophageal adenocarcinoma (400 × magnification).