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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 7, 2014; 20(41): 15060-15069
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15060
Table 2 Drugs and colorectal cancer prevention
Role on CRC preventionEvaluated in randomized clinical trailsRecommendation for general populationRecommendation for high risk population
AspirinLogan et al[34], 2008 Baron et al[61], 2003 Sandler et al[62], 2003 Benamouzig et al[63], 2011 Rothwell et al[65], 2010NoAspirin supplementation Dose: 80-1200 mg/d
NSAIDsArber et al[69], 2006 Baron et al[70], 2006 Bertagnolli et al[71], 2006NoNo, due to toxicity profile
AntioxidantsLippman et al[76], 2009 Greenberg et al[77], 1994NoNo
StatinsPedersen et al[80], 1996 Sacks et al[81], 1996 Emberson et al[82], 2012NoNo
BisphosphonatesNoNoNo
Postmenopausal hormonal therapyChlebowski et al[93], 2004NoNo, due to toxicity profile