Clinical management of advanced gastric cancer: The role of new molecular drugs

doi:10.3748/wjg.v20.i40.14537

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Oct 28, 2014 (publication date) through Sep 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2014; 20(40): 14537-14558
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14537

Table 2 Phase II trials of epidermal growth factor receptor tyrosine kinase inhibitors for advanced gastric cancer and gastro-esophageal junction cancers

Author/trial	Phase	Setting	Regimen	Patients (n)	RR	OS (mo)	TTP (mo)
NCT00237900[86], 2010	II	Neoadjuvant	CF + G + RT	80	-	42% (3-yr)	-
SWOG 0127[89], 2006	II	1^st line	Erlotinib 150 mg/d	44 (GEJ)	9% (GEJ)	6.7 (GEJ)	-
SWOG 0127[89], 2006	II	1^st line	Erlotinib 150 mg/d	26 (stomach)	0% (stomach)	3.5 (stomach)	-

C: Cisplatin; F: 5 fluorouracil; G: Gefitinib; RT: Radiotherapy; RR: Response rate; OS: Overall survival; TTP: Time to progression; GEJ: Gastro-esophageal junction.

Citation: Vita FD, Martino ND, Fabozzi A, Laterza MM, Ventriglia J, Savastano B, Petrillo A, Gambardella V, Sforza V, Marano L, Auricchio A, Galizia G, Ciardiello F, Orditura M. Clinical management of advanced gastric cancer: The role of new molecular drugs. World J Gastroenterol 2014; 20(40): 14537-14558
URL: https://www.wjgnet.com/1007-9327/full/v20/i40/14537.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i40.14537