Accumulation of aberrant DNA methylation during colorectal cancer development

Table 1 Colorectal carcinogenic pathways and genetic alterations

	MSI	Methylation	KRAS	BRAF	TP53	Reports
Adenoma-carcinoma sequence	-	+/-	++	-	+	Grady et al[1]
						Vogelstein et al[3]
Serrated pathway	+	++	+	++	+/-	Howkins et al[32]
						Weisenberger et al[35]
De novo pathway	-	-	+	-	-	Yashiro et al[58]
						Kinney et al[59]

MSI: Microsatellite instability.