Biopsy-driven diagnosis in infants with cholestatic jaundice in Iran

Table 3 Frequencies of selected variables for each diagnosed cause of infantile cholestasis n (%)

Variable		Frequency	BA	INH	Paucity of bile ducts	Choledochal cyst	Metabolic disease	Cirrhosis	PFIC and portal fibrosis
Sex	Female	28 (50.9)	20	3	1	1	2	0	1
	Male	27 (49.1)	12	2	5	1	4	2	1
Maturity	Preterm	15 (27.3)	8	3	1	0	1	1	1
	Term	40 (72.7)	24	2	5	2	5	1	1
Birth weight	Low	15 (27.3)	7	3	1	1	0	2	1
	Normal	40 (72.7)	25	2	5	1	6	0	1
Perinatal findings	Bacterial infection	5 (9.0)	3	0	0	0	1	0	1
	Congenital anomalies	10 (18.0)	4	1	1	2	0	2	0
	Parenteral nutrition	1 (2.0)	0	0	0	0	0	1	0
	Seizure	3 (5.5)	3	0	0	0	0	0	0
	Meconium stained amniotic fluid	4 (7.2)	2	0	2	0	0	0	0
	Fetomaternal hemorrhage	1 (2.0)	1	0	0	0	0	0	0
	Apnea	1 (2.0)	1	0	0	0	0	0	0
	Others	13 (23.0)	7	1	2	1	0	2	0
	Nil	31 (56.0)	18	4	3	0	5	0	1
Clinical findings	Dark urine	21 (38.0)	13	3	4	0	1	0	0
	Acholic stool	33 (60.0)	22	2	4	2	3	0	0
	Hepatomegaly	30 (54.5)	19	5	1	0	4	0	1
	Splenomegaly	17 (31.0)	12	2	0	0	2	0	1
	Clubbing	1 (2.0)	0	0	0	0	1	0	0
	Failure to thrive	14 (25.5)	9	1	1	0	2	1	0
	Ascites	8 (14.5)	4	1	1	0	1	0	1
	Jaundice	55 (100)	32	5	6	2	6	2	2
	Pruritus	3 (5.5)	1	0	0	0	1	0	1
Jaundice temporal course	Progressive	33 (60.0)	17	5	2	2	4	1	2
	Intermittent	4 (7.2)	3	0	1	0	0	0	0
	Continuous	6 (10.9)	3	0	1	0	1	1	0

BA: Biliary atresia; INH: Idiopathic neonatal hepatitis; PFIC: Progressive familial intrahepatic cholestasis.