FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation

Figure 5 Farnesoid X receptor expression is decreased and inversely correlated with nonalcoholic fatty liver disease activity score in patients. Expression of farnesoid X receptor (FXR) in patients was detected by immunohistochemical staining. A: Representative FXR staining of liver sections from healthy control subjects and patients with nonalcoholic steatohepatitis (NASH); B: Quantification of FXR-positive cells in each high power field (HPF); C: The correlation between FXR expression and nonalcoholic fatty liver disease activity score (NAS) in NASH patients. ^bP < 0.01 vs health control group.