Real time shear wave elastography in chronic liver diseases: Accuracy for predicting liver fibrosis, in comparison with serum markers

Table 4 Comparison of diagnostic performance between noninvasive serum marker for discriminating F0-1 vs F2-4 (significant fibrosis), F0-2 vs F3-4 (advanced fibrosis) and F0-3 vs F4 (cirrhosis) (n =61)

	AUROC	95%CI	Pairwise comparison of ROC curves
			Factor	Difference between areas (95%CI)	P value
Significant fibrosis
SWE	0.908	0.806-0.967	HA	0.097 (-0.012-0.205)	0.081
			Type IV	0.067 (-0.003-0.167)	0.189
			APRI	0.217 (0.074-0.359)	0.003
HA	0.812	0.691-0.900	Type IV	0.030 (-0.092-0.152)	0.634
			APRI	0.120 (-0.041-0.281)	0.145
Type IV	0.841	0.725-0.922	APRI	0.150 (-0.006-0.305)	0.059
APRI	0.691	0.560-0.803
Advanced fibrosis
SWE	0.893	0.787-0.957	HA	0.004 (-0.093-0.101)	0.939
			Type IV	0.017 (-0.080-0.113)	0.735
			APRI	0.150 (0.013-0.287)	0.032
HA	0.897	0.792-0.960	Type IV	0.020 (-0.074-0.115)	0.671
			APRI	0.154 (0.014-0.293)	0.031
Type IV	0.876	0.767-0.947	APRI	0.133 (-0.010-0.277)	0.069
APRI	0.743	0.615-0.846
Cirrhosis
SWE	0.877	0.768-0.947	HA	0.002 (-0.114-0.118)	0.974
			Type IV	0.027 (-0.084-0.138)	0.631
			APRI	0.194 (0.031-0.358)	0.002
HA	0.879	0.770-0.948	Type IV	0.029 (-0.072-0.130)	0.571
			APRI	0.196 (0.022-0.371)	0.027
Type IV	0.850	0.736-0.928	APRI	0.167 (-0.003-0.338)	0.055
APRI	0.683	0.551-0.796

ROC: Receiver-operating characteristic curves; AUROC: Area under the ROC curve; SWE: Shear wave elastography; HA: Hyaluronic acid; Type IV: Type IV collagen; APRI: Aspartate aminotransferase to platelet ratio index.