Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 14, 2014; 20(38): 13863-13878
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.13863
Table 4 Prothrombotic abnormalities of hemostasis and coagulation in inflammatory bowel disease patients
CategoryAbnormality
Coagulation factors↑ V, VIII, vWf, and fibrinogen
Products of thrombin generation↑ F1 + 2, TAT
Products of fibrin formation↑ fibrinopeptide A, D-Dimers
Vascular endothelium activation↑ vWf, thrombomodulin
Acquired deficiencies and dysfunction of natural anticoagulants↓ protein C, protein S, and AT
Defects in fibrinolytic system↓ t-PA
↑ PAI-1
Platelets↑ number, activation and aggregation