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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 7, 2014; 20(37): 13343-13368
Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13343
Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13343
Table 2 Target genes of gene therapy in pancreatic cancer
| Strategy | Categories | Examples |
| Gene augumentation | Tumor suppressor genes | p16INK4a, p21CIP1/WAF1, p14ARF, Retinoblastoma Protein (pRb), p53, p84 /Thoc1, p73, Smad4/DPC4 |
| Drug sensitivity genes/ suicide genes | Herpes Simplex Virus Thymidine Kinase (HSV-TK), Cytosine Deaminase (CD), Nitroreductase (NTR), Cytochrome P450 (CYP) | |
| Anti-angiogenesis genes | Soluble VEGFR, Soluble FGFR, Endostatin, Thrombospondin-1, Angiostatin, Vasostatin, NK4, Matrix metalloproteinases inhibitors (MMIPs/TIMPs), Somatostatin receptors (SSTR) | |
| Immune related genes | MHC molecules, Co-stimulatory molecules (B7 family, ICAM-1, LFA-3), Inflammatory cytokines (IL-2, IL-12, GM-CSF, IFN-α, IFN-β, IFN-γ, TNF-α), Tumor antigen (CEA, MUC-1, etc.) | |
| Apoptosis related genes | TRAIL | |
| Gene blockade/antisense therapy | Oncogenes | K-ras, LSM1/CaSm, HER-2/EerB-2 |
| MDR | MDR1, MRP family, BCRP | |
| Proliferation related genes | VEGF, hTERT, COX-2 |
- Citation: Liu SX, Xia ZS, Zhong YQ. Gene therapy in pancreatic cancer. World J Gastroenterol 2014; 20(37): 13343-13368
- URL: https://www.wjgnet.com/1007-9327/full/v20/i37/13343.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i37.13343