Hematologic manifestations of Helicobacter pylori infection

Table 2 Association between immune thrombocytopenia and Helicobacter pylori infection in adults n (%)

Ref.	Year	Country	Patients with ITP	H. pylori-infected ITP patients	Treated patients	H. pylori-eradicated patients	Patients with platelet response
Gasbarrini et al[154]	1998	Italy	18	11 (61.1)	11	8 (72.7)	8 (100)
Emilia et al[155]	2001	Italy	30	13 (43.3)	13	12 (92.3)	6 (50.0)
Emilia et al[156]	2002	Italy	7	3 (42.9)	3	3 (100)	2 (66.7)
Veneri et al[157]	2002	Italy	35	25 (71.4)	16	15 (93.8)	11 (73.3)
Veneri et al[158]	2005	Italy	43	43 (100)	43	41 (95.3)	20 (48.8)
Stasi et al[159]	2005	Italy	137	64 (46.7)	52	52 (100)	17 (32.7)
Suvajdzic et al[162]	2006	Serbia	54	39 (72.2)	30	23 (76.7)	6 (26.1)
Sayan[161]	2006	Turkey	34	20 (58.8)	20	18 (90.0)	8 (44.0)
Emilia et al[160]	2007	Italy	75	38 (50.7)	38	34 (89.5)	23 (67.6)
Scandellari et al[204]	2009	Italy	62	32 (51.6)	16	16 (100)	7 (43.8)
Subtotal European continent			495	288 (58.2)	242	222 (91.7)	108 (48.6)
Kohda et al[163]	2002	Japan	40	25 (62.5)	19	19 (100)	12 (63.2)
Kohda et al[164]	2003	Japan	51	31 (60.8)	26	24 (92.3)	14 (58.3)
Ando et al[165]	2003	Japan	61	50 (82.0)	29	27 (93.1)	13 (48.1)
Hashino et al[166]	2003	Japan	22	14 (63.6)	14	13 (92.9)	5 (38.5)
Hino et al[167]	2003	Japan	30	21 (70.0)	21	18 (85.7)	10 (55.6)
Kato et al[168]	2004	Japan	20	20 (100)	20	17 (85.0)	11 (64.7)
Ando et al[169]	2004	Japan	20	17 (85.0)	17	15 (88.2)	10 (66.7)
Nomura et al[170]	2004	Japan	42	28 (66.7)	28	28 (100)	15 (53.6)
Sato et al[171]	2004	Japan	53	39 (73.6)	32	27 (84.4)	15 (55.6)
Takahashi et al[172]	2004	Japan	20	15 (75.0)	15	13 (86.7)	7 (53.8)
Fujimura et al[173]	2005	Japan	435	300 (69.0)	228	161 (70.6)	101 (62.7)
Inaba et al[174]	2005	Japan	35	25 (71.4)	25	25 (100)	11 (44.0)
Tsutsumi[175]	2005	Japan	25	17 (68.0)	9	9 (100)	6 (66.7)
Suzuki et al[176]	2005	Japan	36	25 (69.4)	13	11 (84.6)	6 (54.5)
Asahi et al[177]	2006	Japan	37	26 (70.3)	26	26 (100)	16 (61.5)
Ishiyama et al[178]	2006	Japan	14	14 (100)	14	14 (100)	8 (57.1)
Satake et al[179]	2007	Japan	38	26 (68.4)	26	23 (88.5)	13 (56.5)
Kodama et al[180]	2007	Japan	116	67 (57.8)	52	44 (84.6)	27 (61.4)
Kong et al[186]	2008	China	31	31 (100)	31	31 (100)	23 (74.2)
Rostami et al[188]	2008	Iran	129	79 (61.2)	71	62 (87.3)	30 (48.4)
Asahi et al[181]	2008	Japan	34	23 (67.6)	23	23 (100)	14 (60.9)
Suzuki et al[182]	2008	Japan	36	36 (100)	36	31 (86.1)	20 (64.5)
Wu et al[187]	2009	Chine	31	31 (100)	31	31 (100)	21 (67.7)
Tsumoto et al[183]	2009	Japan	30	21 (70.0)	21	20 (95.2)	10 (50.0)
Tag et al[190]	2010	South Korea	25	23 (92.0)	23	23 (100)	11 (47.8)
Sato et al[184]	2011	Japan	31	31 (100)	31	31 (100)	18 (58.1)
Kikuchi et al[185]	2011	Japan	31	19 (61.3)	19	19 (100)	10 (52.6)
Payandeh et al[189]	2012	Iran	52	35 (67.3)	29	26 (89.7)	15 (57.7)
Subtotal Asian continent			1525	1089 (71.4)	929	811 (87.3)	472 (58.2)
Campuzano-Maya[191]	2007	Colombia	32	29 (90.6)	29	26 (89.7)	21 (80.8)
Jackson et al[192]	2008	Canada	22	4 (18.2)	4	3 (75.0)	3 (100)
Subtotal American continent			54	33 (90.6)	33	29 (87.9)	24 (82.8)
Total worldwide			2074	1410 (68.0)	1204	1062 (88.2)	604 (56.9)

H. pylori: Helicobacter pylori; ITP: Immune thrombocytopenic purpura.