S-1-based vs non-S-1-based chemotherapy in advanced gastric cancer: A meta-analysis

Table 4 Comparison of toxicity between S-1-based chemotherapy and 5-fluorouracil- or capecitabine-based chemotherapy

Toxicity	S-1 vs 5-FU		S-1 vs capecitabine
	RR	P value	RR	P value
Hematologic
Anemia	1.073	0.794	1.914	0.145
Neutropenia	1.023	0.964	0.475	0.066
Thrombocytopenia	0.683	0.096	0.953	0.903
Leukopenia	0.584	0.002	1.788	0.402
Nonhematologic
Fatigue	1.091	0.558	0.428	0.139
Vomiting	0.801	0.268	0.925	0.928
Nausea	0.791	0.179	1.177	0.812
Diarrhea	1.988	0.436	0.693	0.601
Anorexia	1.057	0.736	1.164	0.794
Weight decreased	0.625	0.082	Not applicable	Not applicable
Stomatitis/mucosal inflammation	0.230	0.032	Not applicable	Not applicable
Neuropathy, peripheral	0.808	0.722	Not applicable	Not applicable
Palmar-plantar erythrodysesthesia	1.770	0.468	0.193	0.133

5-FU: 5-fluorouracil.