Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy

doi:10.3748/wjg.v20.i33.11871

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2014; 20(33): 11871-11877
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11871

Table 3 Patient parameters in patients with or without liver dysfunction after major liver resection

Parameters	Liver dysfunction (n = 135)	No Liver dysfunction (n = 430)	OR (95%CI)	P value
Male	127 (94.1)	357 (83.0)	2.87 (1.42-5.79)	0.001
Age > 65 yr	12 (8.9)	62 (14.4)	0.58 (0.30-1.11)	0.097
Preoperative platelet < 100 × 10⁹/L	37 (27.4)	70 (16.3)	1.94 (1.23-3.07)	0.004
Postoperative platelet < 100 × 10⁹/L	46 (34.1)	100 (23.3)	1.71 (1.12-2.60)	0.012
BMI (kg/m²), mean (SD)	22.9 (21.2-25.0)	22.5 (20.9-24.5)	Not available	0.147
Esophageal varices	36 (26.7)	33 (7.7)	4.38 (2.60-7.37)	0.001
Hypertension	22 (16.3)	74 (17.2)	0.94 (0.56-1.58)	0.805
Cardiovascular disease	4 (3.0)	11 (2.6)	1.16 (0.36-3.71)	0.799
Pulmonary disease	2 (1.5)	10 (2.3)	0.63 (0.14-2.92)	0.802
Diabetes mellitus	10 (7.4)	38 (8.8)	0.83 (0.4-1.70)	0.603
ASA III-IV	17 (12.6)	62 (14.4)	0.86 (0.48-1.52)	0.594
HBsAg	119 (88.1)	335 (77.9)	2.11 (1.19-3.73)	0.009
HBeAg	24 (17.8)	56 (13.0)	1.44 (0.86-2.44)	0.167
HBV DNA > 2000 U/mL	47 (34.8)	139 (32.3)	1.12 (0.74-1.68)	0.591
AST (U/L) > ULN	75 (55.6)	187 (43.5)	1.62 (1.1-2.40)	0.014
ALT (U/L) > ULN	55 (40.7)	127 (29.5)	1.64 (1.10-2.50)	0.015
Total bilirubin (μmol/L), median (IQR)	16.1 (11.4-20.5)	12.5 (9.6-17.4)	Not available	< 0.001
Hemoglobin (g/L), median (IQR)	146 (131-157)	139 (127-150)	Not available	0.001
Liver volume removed				< 0.001
< 35%	15 (11.1)	145 (33.7)	1 (reference)
35%-65%	32 (23.7)	97 (22.6)	3.19 (1.64-6.20)
> 65%	88 (65.2)	188 (43.7)	4.53 (2.51-8.15)
Extrahepatic procedures	37 (27.4)	86 (20.0)	1.51 (0.97-2.36)	0.069
Liver resection with				0.248
Hooking with ligation	38 (28.1)	100 (23.3)	1.29 (0.84-2.0)
Ultrasonic dissection	97 (71.9)	330 (76.7)	0.77 (0.5-1.20)
Inﬂow occlusion	54 (40.0)	197 (45.8)	1.27 (0.86-1.88)	0.236
Anatomic resection	98 (72.6)	289 (67.2)	1.29 (0.84-1.98)	0.240
Blood loss (mL), mean (SD)	770 (1049)	585 (433.0)	Not available	0.003
PRBCs transfusion	47 (34.8)	116 (27.0)	1.45 (0.96-2.19)	0.080
Hospital stay (d), median (IQR)	14 (11-19)	13 (11-16)	Not available	0.001

BMI: Body mass index; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; SD: Standard deviation; ULN: Upper limit of normal; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; IQR: Interquartile range.

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Citation: Wang HQ, Yang J, Yang JY, Wang WT, Yan LN. Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy. World J Gastroenterol 2014; 20(33): 11871-11877
URL: https://www.wjgnet.com/1007-9327/full/v20/i33/11871.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i33.11871

Wang HQ, Yang J, Yang JY, Wang WT, Yan LN. Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy. World J Gastroenterol 2014; 20(33): 11871-11877 [PMID: 25206294 DOI: 10.3748/wjg.v20.i33.11871]

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