Lower serum folate is associated with development and invasiveness of gastric cancer

Table 3 Associations between serum folate levels and clinicopathological features of gastric cancer n (%)

	Folate		Odds ratio1
	> 2.61 ng/mL	≤2.61 ng/mL	95%CI	P value2
Stage
Early (n = 28)	14 (50.0)	14 (50.0)	1
Advanced (n = 127)	54 (42.5)	73 (57.5)	1.38 (0.60-3.14)	NS
Serosal invasion
Absent (n = 43)	26 (60.5)	17 (39.5)	1
Present (n = 112)	42 (37.5)	70 (62.5)	2.54 (1.23-5.23)	< 0.05
Lymph node metastasis
Absent (n = 51)	26 (51.0)	25 (49.0)	1
Present (n = 104)	42 (40.4)	62 (59.6)	1.54 (0.78-3.02)	NS
Venous invasion
Absent (n = 90)	42 (46.7)	48 (53.3)	1
Present (n = 65)	26 (40.0)	39 (60.0)	1.32 (0.69-2.52)	NS
Lymphatic invasion
Absent (n = 74)	40 (54.1)	34 (45.9)	1
Present (n = 81)	28 (34.6)	53 (65.4)	2.23 (1.17-4.26)	< 0.05
Liver metastasis	(> 1.9 ng/mL)	( ≤ 1.90 ng/mL)
Absent (n = 146)	104 (71.2)	42 (28.8)	1
Present (n = 8)	2 (25.0)	6 (75.0)	6.67 (1.28-34.91)	<0.05

¹Age and gender were adjusted by multivariate regression analysis;

²All P values ≥ 0.05 were considered to be statistically non-significant (NS).