Relationship between methylation and colonic inflammation in inflammatory bowel disease

doi:10.3748/wjg.v20.i30.10591

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2014; 20(30): 10591-10598
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10591

Table 3 Methylation status and disease activity according to disease location

Variable (% samples)	Distal colon	Proximal colon	Pvalue
Endoscopic activity¹	48/101 (48)	21/121 (17)	< 0.001
Active histological activity²	30/97 (31)	16/115 (13)	0.004
Methylation of SLIT²	43/101 (43)	23/121 (19)	< 0.001
Methylation of TGFB²	24/90 (27)	16/117 (14)	0.022

¹Endoscopic activity was defined as Mayo > 0 for ulcerative colitis or Crohn’s disease activity index of severity > 0 for Crohn’s disease;

²Active histological activity was defined as the presence of neutrophils in conjunction with epithelial cell damage.

Citation: Lobatón T, Azuara D, Rodríguez-Moranta F, Loayza C, Sanjuan X, de Oca J, Fernández-Robles A, Guardiola J, Capellá G. Relationship between methylation and colonic inflammation in inflammatory bowel disease. World J Gastroenterol 2014; 20(30): 10591-10598
URL: https://www.wjgnet.com/1007-9327/full/v20/i30/10591.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i30.10591