Prognostic nutritional index predicts postoperative complications and long-term outcomes of gastric cancer

Table 3 Univariate and multivariate Cox regression analyses of prognostic factors in patients with gastric cancer undergoing total gastrectomy

Characteristic	n	5-yr OS	Univariate analysis		Multivariate analysis
			χ2	Pvalue	HR (95%CI)	Pvalue
Age (yr)			3.753	0.053
< 65	248	44.4
≥ 65	138	37.0
Gender			0.000	1.000
Female	127	41.7
Male	259	41.7
Tumor location			9.998	0.019
Upper 1/3	119	35.5
Middle 1/3	46	47.8
Lower 1/3	175	48.6
2/3 or more	461	28.3
BMI			11.744	0.001	1.405 (1.021-1.935)	0.037
< 18.5 kg/m2	67	26.9
≥ 18.5 kg/m2	319	44.8
Bleeding			11.786	0.001	1.346 (1.018-1.780)	0.037
≤ 200 mL	150	51.3
> 200 mL	236	35.6
Tumor size			27.632	< 0.001
< 5 cm	144	57.6
≥ 5 cm	242	32.2
Borrmann type			1.613	0.204
I/II	142	46.5
III/IV	244	38.9
Histology			4.831	0.028
Differentiated	102	51.0
Undifferentiated	284	38.4
Extranodal metastasis			17.018	< 0.001
Positive	70	45.6
Negative	316	24.3
Serosal invasion			30.363	< 0.001	1.736 (1.115-2.703)	0.015
Yes	310	69.7
No	76	34.8
Lymph node metastasis			131.31	< 0.001	1.685 (1.487-1.908)	< 0.001
pN0	124	71.8
pN1	58	46.6
pN2	83	36.1
pN3	121	12.4
TNM stage			78.584	< 0.001
I	39	84.6
II	100	63.0
III	247	26.3
Postoperative complications			15.175	< 0.001	1.453 (1.079-1.956)	0.014
Yes	83	22.9
No	303	46.9
Chemotherapy			2.750	0.097
Yes	224	48.1
No	162	37.1
PNI					2.074 (1.581-2.722)	< 0.001
High	245	54.1	60.703	< 0.001
Low	141	21.1

PNI: Prognostic nutritional index; BMI: Body mass index.