Length of negative resection margin does not affect local recurrence and survival in the patients with gastric cancer

Table 5 Survival related factors in advanced gastric cancer

Clinicopathologic factors	Univariable analysis for OS (P value, HR)	Multivariable analysis for OS (P value, HR)	Univariable analysis for RFS (P value, HR)	Multivariable analysis for RFS (P value, HR)
Sex	0.449, 1.113		0.306, 1.150
Age	0.025, 1.013	0.001, 1.020	0.470, 0.996
Size of the tumor	< 0.001, 1.139	0.127, 1.046	< 0.001, 1.177	0.012, 1.081
Operation method	0.029, 1.361	0.145, 0.727	0.004, 1.474	0.091, 0.697
Lymphatic invasion	< 0.001, 3.537	0.696, 1.094	< 0.001, 3.082	0.975, 0.993
Vascular invasion	< 0.001, 2.876	0.026, 1.428	< 0.001, 2.868	0.094, 1.313
Perineural invasion	< 0.001, 2.440	0.343, 1.189	< 0.001, 2.342	0.634, 1.092
Borrmann type	< 0.001	0.087	< 0.001	0.05
WHO Classification	0.025, 1.389	0.856, 1.030	0.003, 1.537	0.169, 1.745
Lauren Classification	0.099, 1.281		0.004, 1.530	0.165, 0.572
Harvested lymph node	0.191, 1.004		0.288, 1.003
Positive lymph node	< 0.001, 1.048	0.001, 1.021	< 0.001, 1.047	< 0.001, 1.021
PM	0.278, 0.970		0.207, 0.966
DM	0.047, 0.969	0.660, 1.009	0.035, 0.968	0.670, 1.009
Stage	< 0.001	< 0.001	< 0.001	< 0.001

Age, size of the tumor, harvested lymph node, positive lymph node, PM, DM were included as continuous values in this analysis. AGC: Advanced gastric cancer; OS: Actual 3-year overall survival; RFS: Actual 3-year recurrence-free survival; PM: The length of proximal resection margin; DM: The length of distal resection margin.