Medicinal plant activity on Helicobacter pylori related diseases

Table 3 Anti-Helicobacter pylori activity of compounds from plants

Compound	Original plant	MIC/MBC	Ref.
Phenolics/Simple phenols/Polyphenols
Boropinic acid	Boronia pinnata	MIC: 1.62 μg/mL	Epifano et al[82]
	Sm.
Corilagin, 1,2,3,6-tetra-O-galloyl-b-D-glucose	Geranium wilfordii	MIC: 2-8 μg/mL	Zhang et al[83]
Egallic acid	Rubus ulmifolius leaves	MIC: 2-10 μg/mL	Martinia et al[66]
3-Farnesyl-2-hydroxybenzoic acid	Piper multiplinervium	MIC: 3.75-12.5 μg/mL	Rüegg et al[84]
Epigallocatechin gallate, epicatechin gallate, epigallocatechin,		MIC: 8-256 μg/mL	Mabe et al[85]
epicatechin
Magnolol	Magnoliae officinalis	MIC: 10-20 μg/mL	Bae et al[86]
Psoracorylifols	Psoralea corylifolia	MIC: 12.5-25 μg/mL	Yin et al[87]
Resveratrol	Red wine	MIC: 25-100 μg/mL	Paulo et al[88]
Cinnamic acid		MIC: 80-200 μg/mL	Bae et al[86]
Allixin	Allium sativum	MIC90: 50 μg/mL	Mahady et al[89]
Paeonol, benzoic acid, methyl gallate,	Paeonia lactiflora Roots	MIC: 80-320 μg/mL	Ngan et al[90]
1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose		MBC: 320-1280 μg/mL
Including 3-hydroxy-2,2-dimethyl-8-prenylchromane-6-propenoic	Brazilian propolis	MIC: 130-1000 μg/mL	Banskota et al[91]
acid 10 phenolic acids
Chlorogenic acid	Anthemis altissima	MIC: 312.5-1250 μg/mL	Konstantinopoulou et al[92]
Flavonoids
Quercetin 3-methyl ether,	Cistus laurifolius leaves	MIC: 3.9-62.5 μg/mL	Ustün et al[93]
quercetin 3,7-dimethyl ether, kaempferol 3,7-dimethyl ether
Kaempferol	Rubus ulmifolius leaves	MBC: 6 μg/mL	Martinia et al[66]
Kaempferol 4’-methyl ether, quercetin, rhamnetin, isoquercetrin,	Anthemis altissima	MIC: 6.25-50 μg/mL	Konstantinopoulou et al[92]
taxifolin, eriodictyol
Including licoisoflavone B and licoricidin 16 flavonoids	Licorice	MIC: 6.25-50 μg/mL	Fukai et al[94]
Cabreuvin	Myroxylon peruiferum	MIC: 7.8 μg/mL	Ohsaki et al[57]
3,5,7-Trihydroxy-4’-methoxyflavanol, keampferol-3,4’-dimethyl ether	Brazilian propolis	MIC: 500-1000 μg/mL	Banskota et al[91]
Quinones
2-Methoxy-1,4-naphthoquinone	Impatiens balsamina L.	MIC: 0.156-0.625 μg/mL	Wang et al[95]
		MBC: 0.313-0.625 μg/mL
2-(Hydroxymethyl)anthraquinone, anthraquinone-2-carboxylic acid,	Tabebuia impetiginosa	MIC: 2-8 μg/mL	Park et al[96]
Lapachol, plumbagin	Martius ex DC
Idebenone, duroquinone, menadione, juglone, benzoquinone,		MIC90: 0.8-25 μg/mL	Inatsu et al[97]
coenzyme Q1, coenzyme Q10, decylubiquinone
Emodin	Rhei Rhizoma	MIC86-99: 250 μg/mL	Wang and Chung[98]
Coumarins
Benzoyl aegelinol, aegelinol	Ferulago campestris (Apiaceae) roots	MIC: 5-25 μg/mL	Basile et al[99]
24 Synthetic coumarin derivatives		MIC: 10-40 μg/mL	Jadhav et al[100]
23 Synthetic coumarin derivatives		MIC50: 23->100 μg/mL	Kawase et al[101]
Terpenoids
Arjunglucoside I	Pteleopsis suberosa	MIC: 1.9-7.8 μg/mL	De Leo et al[102]
Trichorabdal	Rabdosia trichocarpa	MIC: 2.5-5 μg/mL	Kadota et al[103]
Sivasinolide, altissin, 1-epi-tatridin B, desacetyl-β-cyclopyrethrosin,	Anthemis altissima	MIC: 12.5-50 μg/mL	Konstantinopoulou et al[92]
tatridin-A
(Z)-R-santalol (7), (Z)-β-santalol, (Z)-lanceol	Santalum album	MIC: 7.8-31.3 μg/mL	Ochi et al[104]
Stigmasta-7,22-diene-3β-ol	Impatiens balsamina L.	MIC: 20-80 μg/mL	Wang et al[95]
		MBC: 20-80 μg/mL
Plaunotol	Plau-noi	MIC90: 12.5 mg/mL	Koga et al[105]
Terpinen-4-ol	Sclerocarya birrea (Anacardiaceae)	MIC50: 0.004-0.06 μg/mL	Njume et al[106]
Alkaloids
1-Methyl-2-[(Z)-8-tridecenyl]-4-(1H)-quinolone,	Evodia rutaecarpa fruits	MIC: < 0.05 μg/mL	Hamasaki et al[107]
1-Methyl-2-[(Z)-7-tridecenyl]-4-(1H)-quinolone
Tryptanthrin	Polygonum tinctorium Lour.	MIC: 2.5 μg/mL	Hashimoto et al[108]
Other compounds
Pyrrolidine	Sclerocarya birrea (Anacardiaceae)	MIC50: 0.05-6.3 μg/mL	Njume et al[106]
Diallyl disulfide, diallyl trisulfide, diallyl tetrasulfide, allicin		MIC: 3-100 μg/mL	O’gara et al[109]
		MBC: 6-200 μg/mL
Palmitoyl ascorbate		MIC: 40-400 μg/mL	Tabak et al[110]
Capric acid, lauric acid, myristic acid, myristoleic acid,		MBC: 0.5-5 mmol/L	Sun et al[111]
palmitoleic acid, linolenic acid, monolaurin, monomyristin

MIC: Minimum inhibitory concentration; MBC: Minimum bactericidal concentration.