Optimizing clarithromycin-containing therapy for Helicobacter pylori in the era of antibiotic resistance

Table 2 Updated systematic reviews and meta-analyses (2008-2012) in children and adults comparing triple and sequential therapy for Helicobacter pylori infection

Ref.	Population and timeframe	n	Triple therapy (95%CI)	Sequential therapy (95%CI)	P value
Horvath et al[49], 2012	Children 2005-2012	857	71% (66-75)	78% (73-82)
Zullo et al[50], 2013	Adults and children 2008-2012	2921	75.8% (73.5–78.1)	80.6% (78.5–82.7)	0.003
Kate et al[51], 2013	Adults and children 2008-2012	3247	71.4% (64-78)	81.7% (78-85)	0.02