Bowman-Birk inhibitors from legumes as colorectal chemopreventive agents

doi:10.3748/wjg.v20.i30.10305

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2014; 20(30): 10305-10315
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10305

Table 1 Amino acid sequence alignment of Bowman-Birk inhibitor-like proteins from several legumes species

Species	Entry name (accession number)	Amino acid sequence
Dolichos biflorus	IBB_DOLBI (Q9S9E3)	EPSESSKPCCDQCTCTKSIPPQCRCTDVRLNSCHSACSSCVCTFSIPAQCVCVDMKDFCYAPCKSSHDD
Glycine max	IBB1_SOYBN (P01055)	DDESSKPCCDQCACTKSNPPQCRCSDMRLNSCHSACKSCICALSYPAQCFCVDITDFCYEPCKPSEDDKEN
	IBBD2_SOYBN (P1064)	DDEYSKPCCDLCMCTRSMPPQCSCEDIRLNSCHSDCKSCMCTRSQPGQCRCLDTNDFCYKPCKSRDD
	IBBC2_SOYBN (P01063)	DDESSKPCCDLCMCTASMPPQCHCADIRLNSCHSACDRCACTRSMPGQCRCLDTTDFCYKPCKSSDEDDD
Lens culinaris	IBB_LENCU (Q8W4Y8)	GDDVKSACCDTCLCTRSQPPTCRCVDVRESCHSACDKCVCAYSNPPQCQCYDTHKFCYKACHNSEIEE
Lupinus albus	IBB1_LUPAL (P85172)	SLASKPCCDSCLCTRSIPPQCRCTDIGETCHSACKSCICTRSFPPQCRCSDITHFCYKPCTSS
Phaseolus vulgaris	IBB2_PHAVU (P01060)	EPSESSEPCCDICVCTASIPPICQCTDVRLNSCHSACKSCMCTRSMPGKCRCLDTTDYCYKSCKSSGEDDD
	IBB3_PHAVU (P81484)	ASXSSKPCCBHCACTKSIPPQCRCSBLRLNSCHSECKGCICTFSIPAQCICTDTNNFCYEPCKSSHGPBBNN
Pisum sativum	IBBA_PEA (Q41065)	GDDVKSACCDTCLCTKSNPPTCRCVDVRETCHSACDSCICAYSNPPKCQCFDTHKFCYKACHNSEVEEVIKN
	IBB2_PEA (Q41066)	GDDVKSACCDTCLCTKSDPPTCRCVDVGETCHSACDSCICALSYPPQCQCFDTHKFCYKACHNSEVEE VIKN
	IBBB_PEA (P56679)	GDDVKSACCDTCLCTKSNPPTCRCVDVGETCHSACLSCICAYSNPPKCQCFDTQKFCYKACHNSELEEVIKN
Vicia faba	IBB_VICFA (P24661)	GDDVKSACCDTCLCTKSEPPTCRCVDVGERCHSACNSCVCRYSNPPKCQCFDTHKFCYKSCHN
Vigna unguiculata	IBB_VIGUN (P17734)	ZASZSSKPCCRZCACTKSIPPZCRCSZVRLNSCHSACKSCACTFSIPAZCFCGBIBBFCYKPCKSSHSBBBBWN

The primary accession numbers below are reported in UniProtKB database. P₁-P_1’ are the reactive peptide bond sites, in bold text. Either K or R at P₁ position determines specificity for trypsin, whereas L, Y or F determines specificity against chymotrypsin; A determines specificity for elastase.

Citation: Clemente A, Arques MDC. Bowman-Birk inhibitors from legumes as colorectal chemopreventive agents. World J Gastroenterol 2014; 20(30): 10305-10315
URL: https://www.wjgnet.com/1007-9327/full/v20/i30/10305.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i30.10305