Epidermal growth factor upregulates Skp2/Cks1 and p27kip1 in human extrahepatic cholangiocarcinoma cells

Figure 2 Relationship among the immunostaining intensity for S-phase kinase-associated protein 2, Cyclin-dependent kinases regulatory subunit 1, p27^kip1, and Ki-67 LI. Ki-67 LI significantly increased as the staining intensity of Skp2 and Cks1 increased. Ki-67 LI showed no significant correlation with the staining intensity of p27^kip1. Statistical analyses were performed by one-way ANOVA. ^bP < 0.01 between groups. Skp2: S-phase kinase-associated protein 2; Cks1: Cyclin-dependent kinases regulatory subunit 1.