Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis

doi:10.3748/wjg.v20.i29.9872

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2014; 20(29): 9872-9881
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9872

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Figure 1 Molecular pathogenesis of sporadic colon cancer and colon cancer associated with inflammatory bowel disease. Many of the genetic alterations associated with development of sporadic colon cancer also play a role in colitis associated colon cancer. However, the frequency and sequence of these events differ between the cancers. Modified from Ref [21]. APC: Adenomatous polyposis coli; MSI: Microsatellite instability; KAS: Kirsten Rat Sarcoma Viral Oncogene Homolog; COX-2: Cyclooxygenase-2; DCC: Deleted in colorectal carcinoma; DPC4: Deleted in pancreatic carcinoma 4; CIN: Chromosomal instability.

Citation: Kim ER, Chang DK. Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis. World J Gastroenterol 2014; 20(29): 9872-9881
URL: https://www.wjgnet.com/1007-9327/full/v20/i29/9872.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i29.9872