IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions

Figure 3 Kaplan-Meier survival curves for colorectal cancer according to the IGF2 differentially methylated region 0 and long interspersed nucleotide element-1 methylation levels in metastatic colorectal cancers. A: Patients with Insulin-like growth factor 2 (IGF2) differentially methylated region (DMR)0 hypomethylation had a slightly higher mortality rate than those with IGF2 DMR0 hypermethylation, but this difference was not significant (log-rank test: P = 0.13); B: IGF2 DMR0 hypomethylation (Q4 cases) was significantly associated with unfavorable cancer-specific survival (log-rank test: P = 0.038); C: Significantly higher mortality was observed in patients with long interspersed nucleotide element-1 (LINE-1) hypomethylation compared with those with LINE-1 hypermethylation (log-rank test: P = 0.026); D: LINE-1 hypomethylation (Q4 cases) was significantly associated with unfavorable cancer-specific survival (log-rank test: P = 0.0037).