Therapeutic applications of curcumin for patients with pancreatic cancer

Table 2 A summary of published clinical trials testing curcumin in patients with pancreatic cancer

	Dhillon et al[47]	Kanai et al[48]	Epelbaum et al[49]	Kanai et al[69]
Sample size	25	21	17	14
Study design	Phase II	Phase I/II	Phase II	Phase I
Study period	20081	2008-2009	2004-2006	2011-2012
Dose of curcumin	8 g/d	8 g/d	8 g/d	200 mg/d2 (n = 9) 400 mg/d2 (n = 5)
Prior history of chemotherapy	Yes (n = 22)	Yes (n = 21)	None	yes (n = 14)
Concomitant use of anticancer drug	No	Yes	Yes	Yes
Major toxicity associated with curcumin	None	None	Abdominal discomfort (n = 5)	Abdominal pain (n = 2)
Median survival time (mo)	NA	5.4	5	4.4

¹Publication year;

²THERACURMIN^® was used in this study. NA: Not available.