Primary sclerosing cholangitis as an independent risk factor for colorectal cancer in the context of inflammatory bowel disease: A review of the literature

doi:10.3748/wjg.v20.i27.8783

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jul 21, 2014; 20(27): 8783-8789
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8783

Table 1 Summary of studies investigating colorectal cancer as a risk factor in patients with concurrent primary sclerosing cholangitis and inflammatory bowel disease

Ref.	Location	IBD-PSC patients (n)	Colorectal neoplasms (n)	Matched controls?	Study type	Is IBD-PSC a risk for CRC?
[24]	The Netherlands	IBD (126)	CRC (16)	No	Retrospective	Yes
[9]	Belgium	IBD (107)	CRC (10)	No	Retrospective	Yes
[12]	Sweden	IBD (152)	CRC/Dys (3)	No	Retrospective	No
[31]	Germany	IBD (120)	CRC (7)	No	Prospective	Only with dominant stenosis
[28]	Argentina	UC (39)	CRC (7)	Yes	Prospective	Yes
[30]	United States	UC (50)	N/S	Yes	Retrospective	No
[32]	Sweden	CD (28)	CRC/Dys (9)	Yes	Retrospective	Yes
[33]	United Kingdom	CD (35)	Dys (1)	No	Retrospective	No

UC: Ulcerative colitis; CD: Crohn’s disease; Dys: Dysplasia; N/S: Not specified; CRC: Colorectal cancer; PSC: Primary sclerosing cholangitis; IBD: Inflammatory bowel disease.

Citation: Wang R, Leong RM. Primary sclerosing cholangitis as an independent risk factor for colorectal cancer in the context of inflammatory bowel disease: A review of the literature. World J Gastroenterol 2014; 20(27): 8783-8789
URL: https://www.wjgnet.com/1007-9327/full/v20/i27/8783.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i27.8783