Prognostic significance of preoperative fibrinogen in patients with colon cancer

Table 1 Correlations between preoperative fibrinogen and clinicopathological parameters

Parameters	n	Fibrinogen (g/L, mean ± SD)	P value
Age (yr)
< 60	119	3.29 ± 1.01	0.047
≥ 60	136	3.07 ± 0.73
Nationality
Han	216	3.16 ± 0.87	0.892
Uygur	30	3.24 ± 0.92
Others	9	3.12 ± 0.94
BMI (kg/m2)
< 18.5	8	3.54 ± 0.82	0.638
18.5-23.99	115	3.15 ± 0.94
24-27.99	102	3.14 ± 0.83
≥ 28	30	3.23 ± 0.79
Smoking
Never	173	3.06 ± 0.82	0.018
Light	18	3.43 ± 0.74
Heavy	64	3.39 ± 0.99
Grade (tumor differentiation)
Low	203	3.12 ± 0.86	0.080
High	52	3.36 ± 0.92
TNM
I	29	2.70 ± 0.58	0.002
II	139	3.24 ± 0.95
III	87	3.21 ± 0.78
Tumor size (cm)
< 4	51	2.81 ± 0.72	0.000
4-6	114	3.01 ± 0.73
≥ 6	90	3.57 ± 0.98
Type
Mess type	104	3.13 ± 0.87	0.390
Ulceration	148	3.21 ± 0.89
Infiltrative	3	2.58 ± 0.13
Tumor location
Left	155	3.06 ± 0.82	0.020
Right	89	3.38 ± 0.97
Transverse	11	2.99 ± 0.55
Perineural invasion
Yes	7	3.40 ± 0.59	0.488
No	248	3.16 ± 0.88
Vascular invasion
Yes	13	3.29 ± 0.94	0.619
No	242	3.16 ± 0.87
CEA (ng/mL)
< 5	161	3.08 ± 0.89	0.038
≥ 5	94	3.32 ± 0.84
AFP (ng/mL)
< 5	231	3.17 ± 0.88	0.747
≥ 5	24	3.11 ± 0.82
mGPS
0	163	3.00 ± 0.77	0.000
1	71	3.37 ± 0.94
2	21	3.80 ± 1.00
WBC count
< 5 × 109/L	61	2.68 ± 0.56	0.000
≥ 5 × 109/L	194	3.32 ± 0.90
NLR
< 5	238	3.13 ± 0.86	0.013
≥ 5	17	3.69 ± 1.02
PLR
< 150	134	2.96 ± 0.75	0.000
150-300	105	3.41 ± 0.96
> 300	15	3.40 ± 0.83

AFP: Alpha-fetoprotein; BMI: Body mass index; CEA: Carcinoembryonic antigen; mGPS: Modified Glasgow prognostic score; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; TNM: Tumor-node-metastasis; WBC: White blood cell.