Distinct antifibrogenic effects of erlotinib, sunitinib and sorafenib on rat pancreatic stellate cells

Figure 5 Transforming growth factor-β1 concentrations in culture supernatants of small molecule kinase inhibitors-treated pancreatic stellate cells. Cultured pancreatic stellate cells were grown to subconfluency before they were treated for 48 h with Small molecule kinase inhibitors at the indicated concentrations. The concentrations of transforming growth factor (TGF)-β1 in cell culture supernatants were determined by ELISA. Data of n = 6 independent cultures were used to calculate mean ± SE. ^aP < 0.05 vs control cultures (one-way ANOVA test).