Nonalcoholic fatty liver disease: Updates in noninvasive diagnosis and correlation with cardiovascular disease

Table 2 Accuracy of noninvasive diagnosis methods for nonalcoholic steatohepatitis

	Cutoff value	AUROC	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Ref.
Biomarkers
Morbidly obese and AST, ALT	2 times of ULN	-	-	-	21	91	[22]
big-γ GT	2.6 U/L	0.85	74	81	83.7	71.2	[27]
CK-18 M30 antigen	121.6 IU/L	0.787	60	97.4	96.4	67.3	[48]
CK-18 M65 antigen	243.82 IU/L	0.809	68.9	81.6	81.6	68.9	[48]
PIIINP	6.6 ng/mL	-	80	68	60	85	[51]
Predictive Models
APRI	0.98	0.85	75	86	34	93	[55]
FIB-4	1.30	0.86	85	65	36	95	[59]
Image assessment
Transient elastography (TE; FibroScan )	6.7 kPa	0.87	77.5	86.7	94.8	54.9	[66]
ARFI	1.2 m/s	0.84	76.9	86.7	95.7	54.1	[66]
Combine TE and ARFI	TE > 6.7 kPa ARFI > 1.2 m/s	-	60.5	93.3	96.8	41.4	[66]
MRE	2.74 kPa	0.93	94	73	85	89	[71]

ULN: Upper limit of normal; PIIINP: Terminal peptide of procollagen III; APRI: AST-to-platelet ratio index; AFRI: Acoustic radiation force impulse; MRE: Magnetic resonance elastography; AUROC: Area under receiver operating characteristic curve; PPV: Positive predictive value; NPV: Negative predictive value.