Association between orofacial granulomatosis and Crohn’s disease in children: Systematic review

Table 4 Concomitant diseases diagnosed in children with orofacial granulomatosis and associated characteristics n (%)

Disease	Value(n = 173)	RR (95%CI), P
Crohn’s disease
Total children	70 (40.4)
At presentation	34 (19.6)
During follow-up	36 (20.8)
Time from OFG diagnosis to Crohn’s diagnosis (mean ± SD, range)	13.1 ± 11.6 (3-36)
Presence of perianal disease
Total	21/173 (12.1)	3.10 (2.46-3.90), 0.0001
In children with Crohn’s	21/70 (30.0)
In children without Crohn’s	0/103 (0)
Familiarity for inflammatory bowel diseases
Total	11/173 (6.4)	2.74 (2.24-3.36), 0.0001
In children with Crohn’s	11/70 (15.7)
In children without Crohn’s	0/103 (0)
Allergy/atopy
Any allergy	19 (10.9)
Asthma	7 (4.0)
Atopy	6 (3.5)
Rhinitis/rhinoconjunctivitis	6 (3.5)
Eczema	6 (3.5)
Hives	1 (0.6)
Other diagnosis
Tuberculosis	3 (1.7)
Sarcoidosis	2 (1.1)
Other diseases	10 (5.7)
Erythema nodosum	3 (1.7)
Insulin dependent diabetes	1 (0.6)
Celiac disease	1 (0.6)
Alopecia	1 (0.6)
Low CD4/CD8 ratio	1 (0.6)
Epilepsy	1 (0.6)