Hepatitis B virus infection in Latin America: A genomic medicine approach

Table 1 Nucleotide divergence over the complete genome among hepatitis B virus genotypes F and H

Cluster	HMEX	HUSA	HSA	Hnon-Hispanic
F1a	8.63	8.89	8.70	8.51
	(8.11-9.9)	(8.16-9.5)	(8.5-8.8)	(8.22-8.91)
F1b	8.63	8.88	8.59	8.49
	(8.22-10.1)	(8.04-9.86)	(8.19-9.39)	(8.04-9.31)
F2	8.07	8.83	8.77	7.9
	(7.59-9.66)	(8.04-9.86)	(8.09-8.24)	(7.66-8.48)
F3	7.84	7.76	7.94	7.69
	(7.17-9.91)	(7.28-8.94)	(7.24-8.97)	(7.24-8.82)
F4	8.36	8.66	8.50	8.29
	(7.77-10.40)	(7.84-9.98)	(8.06-9.34)	(7.91-9.33)

Evolutionary distances between nucleotide sequences of 61 hepatitis B virus (HBV) genes calculated in accordance with the Gen Bank database. Values correspond to mean percentage of genetic distances of pair-wise analysis. Values in parentheses indicate ranges (bootstrap value 1000; Kimura two parameter method). H_MEX, H_USA, H_SA, H_non-Hispanic, refer to isolates of HBV genotype H from Mexico, United States, South America and Asian subjects, respectively in compliance with Figure 1. MEX: Mexico; SA: South America.