Role of the Na+/K+/2Cl- cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Gastroenterol. Jun 14, 2014; 20(22): 6844-6859
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.6844

Table 3 Top biological functions, canonical pathways, and networks of Na⁺/K⁺/2Cl^- cotransporter 1 according to Ingenuity Pathway Analysis

Top Biological Functions
Diseases and disorders
Name	P value	Number of molecules
Cancer	2.08E-12 - 1.59E-02	277
Gastrointestinal disease	8.03E-12 - 1.60E-02	149
Reproductive system disease	2.25E-09 - 1.57E-02	138
Hematological disease	1.72E-06 - 1.22E-02	70
Hereditary disorder	2.10E-06 - 1.57E-02	120

Molecular and cellular functions
Name	P value	Number of molecules
Cell cycle	1.06E-20 - 1.60E-02	158
Cellular assembly and organization	1.06E-20 - 1.36E-02	111
DNA replication, recombination, and repair	1.06E-20 - 1.16E-02	133
Cellular movement	8.36E-11 - 1.51E-02	82
Cell death	2.98E-06 - 1.56E-02	216
Top canonical pathways
Name	P value	Ratio
Role of BRCA1 in the DNA damage response	9.79E-6	12/65 (0.185)
Mitotic roles of Polo-Like kinase	7.37E-5	11/69 (0.159)
Estrogen-mediated S-phase entry	4.91E-4	6/28 (0.214)
Cell Cycle: G2/M DNA damage checkpoint regulation	5.07E-4	8/49 (0.163)
Role of CHK proteins in cell cycle checkpoint control	5.37E-4	9/56 (0.161)

Top networks
Associated network functions	Score
Cellular assembly and organization; DNA replication, recombination, and repair; Cell cycle	47
Cellular assembly and organization, Cell cycle, DNA replication, recombination, and repair	43
Cell cycle; DNA replication, recombination, and repair; Cancer	37
Digestive system development and function, organismal injury and abnormalities, cellular function and maintenance	37
Cellular assembly and organization; DNA replication, recombination, and repair; Cardiovascular disease	35

Citation: Shiozaki A, Nako Y, Ichikawa D, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E. Role of the Na⁺/K⁺/2Cl^- cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma. World J Gastroenterol 2014; 20(22): 6844-6859
URL: https://www.wjgnet.com/1007-9327/full/v20/i22/6844.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i22.6844

Shiozaki A, Nako Y, Ichikawa D, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E. Role of the Na⁺/K⁺/2Cl^- cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma. World J Gastroenterol 2014; 20(22): 6844-6859 [PMID: 24944475 DOI: 10.3748/wjg.v20.i22.6844]

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