Colorectal cancer: From prevention to personalized medicine

doi:10.3748/wjg.v20.i22.6786

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2014; 20(22): 6786-6808
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.6786

Table 7 Systemic treatment of colon cancer

Adjuvant therapy (stage III and stage II with high-risk features for systemic recurrence)

FOLFOX

CapeOx

If oxaliplatin is contraindicated or elderly patients

Capecitabine

5-FU/Leucovorin

Metastatic disease (stage IV)

Resectable disease (lung, hepatic or peritoneal metastasis)

Consider surgery and/or locoregional treatment (radiofrequency, stereotactic radiotherapy) and 6 mo of perioperative chemotherapy (FOLFOX, CapeOx preferred)

Potentially resectable

FOLFOX

FOLFIRI

FOLFOXIRI

Cetuximab + FOLFIRI (only KRAS wild type)

Panitumumab + FOLFOX (only KRAS wild type)

Bevacizumab + FOLFOX

Unresectable (palliative)

FOLFOX

CapeOx

FOLFIRI

FOLFOX + Bevacizumab

CapeOx + Bevacizumab

FOLFOX + Panitumumab (only KRAS wild type)

FOLFIRI + Panitumumab (only KRAS wild type)

FOLFIRI + Cetuximab (only KRAS wild type)

FOLFIRI + Aflibercept

Capecitabine

5-FU/Leucovorin

Cetuximab + Irinotecan (only KRAS wild type)

Cetuximab monotherapy (only KRAS wild type)

Panitumumab monotherapy (only KRAS wild type)

Regorafenib

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Citation: Binefa G, Rodríguez-Moranta F, Teule &, Medina-Hayas M. Colorectal cancer: From prevention to personalized medicine. World J Gastroenterol 2014; 20(22): 6786-6808
URL: https://www.wjgnet.com/1007-9327/full/v20/i22/6786.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i22.6786

Binefa G, Rodríguez-Moranta F, Teule &, Medina-Hayas M. Colorectal cancer: From prevention to personalized medicine. World J Gastroenterol 2014; 20(22): 6786-6808 [PMID: 24944469 DOI: 10.3748/wjg.v20.i22.6786]

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