Colorectal cancer: From prevention to personalized medicine

doi:10.3748/wjg.v20.i22.6786

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2014; 20(22): 6786-6808
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.6786

Table 5 Serum DNA markers for adenoma and colorectal cancer n (%)

Marker	Study	Sensitivity		Specificity
Marker	Study	CRC	Adenoma
APC, KRAS, p53	Wang et al[185]	36 (46)	-	Specificity	50 (100)
APC mutation	Diehl et al[121]	16 (73)	1 (9)	33 (100)
APC, MLH1, HLTF	Leung et al[186]	3-28 (6-57)	-	37-41 (90-100)
Meth SEPT9	Lofton-Day et al[134]	92 (69)	-	154 (86)
	Grützmann et al[133]	73 (58)	3 (18)	165 (90)
	deVos et al[131]	62 (69)	-	132 (89)
	Tóth et al[187]	88 (96)	-	78 (85)
TMEF2, NGFR, SEPT9	Lofton-Day et al[134]	40-69 (30-52)	-	170 (95)
Meth on 10 genes	Lee et al[188]	210 (87)	48 (75)	254 (92)
Meth Vimentin	Li et al[168]	48 (59)	-	102 (93)

TMEF2: Transmembrane protein with EGF–like and follistatin–like and two follistatin-like domains 2; SEPT9: Septin 9; Meth: Methylation; CRC: Colorectal cancer; APC: Adenomatous polyposis coli gene; MLH1: MutL homolog 1; HLTF: Helicase-like transcription factor.

Citation: Binefa G, Rodríguez-Moranta F, Teule &, Medina-Hayas M. Colorectal cancer: From prevention to personalized medicine. World J Gastroenterol 2014; 20(22): 6786-6808
URL: https://www.wjgnet.com/1007-9327/full/v20/i22/6786.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i22.6786